Dopamine Receptor
Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.
Dopamine Receptor Isoform Specific Products
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Dopamine Receptor Inhibitors
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Dopamine Receptor Agonists
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Dopamine Receptor Antagonists
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Dopamine Receptor Chemical
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Dopamine Receptor MDM2 Inhibitor
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Dopamine Receptor Controls
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Dopamine Receptor Ligands
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Dopamine Receptor Related Products (1078)
Related Products (1078)
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Antibodies (7)
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Related Compound Screening Libraries (1)
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Dopamine Receptor Isoform Comparison
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Ocaperidone (Standard)
0 ImagesCat. No.: HY-101094RCAS No.: 129029-23-8Synonyms: R79598 (Standard)Ocaperidone (Standard) is the analytical standard of Ocaperidone (HY-101094). This product is intended for research and analytical applications. Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.
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Pericyazine (Standard)
0 ImagesSynonyms: Propericiazine (Standard); RP 8909 (Standard)Pericyazine (Standard) is the analytical standard of Pericyazine. This product is intended for research and analytical applications. Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis. Pericyazine is a selective D2-dopamine receptor antagonist. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects.
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S-14506 hydrochloride (Standard)
0 ImagesCat. No.: HY-110024RCAS No.: 286369-38-8S-14506 hydrochloride (Standard) is the analytical standard of S-14506 (hydrochloride) (HY-110024). This product is intended for research and analytical applications. S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocKing dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent.
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(±) Anabasine hydrochloride
0 ImagesCat. No.: HY-W209279CAS No.: 352220-15-6(±) Anabasine hydrochloride is the racemic form of Anabasine (HY-B1532). (±) Anabasine hydrochloride stimulates the release of [3H]-Dopamine from mouse striatal synaptosomes. (±) Anabasine hydrochloride inhibits the high-affinity binding of [3H]-S-(-)-Nicotine to the striatal membrane. Anabasine hydrochloride is an agonist of α7nAChR and possesses anti-inflammatory and insecticidal activities.
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Alentemol hydrobromide
0 ImagesCat. No.: HY-115418CAS No.: 112892-81-6Synonyms: U-68553BAlentemol hydrobromide (U-66444B) is a blood-brain barrier-permeable dopamine receptor D1, D2, D3, and D4 agonist. Alentemol hydrobromide inhibits dopamine release, reduces dopamine synthesis, regulates dopamine metabolism, suppresses the impulse activity of dopaminergic neurons, and decreases the impulse frequency of dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area. Alentemol hydrobromide is applicable to research related to schizophrenia.
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Ropinirole-d3 hydrochloride
0 ImagesCat. No.: HY-B0623AS2CAS No.: 1329611-00-8Synonyms: SKF 101468-d3 hydrochlorideRopinirole-d3 hydrochloride is the deuterium labeled Ropinirole hydrochloride. Ropinirole (SKF 101468) hydrochloride is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease.
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ADR 851 free base
0 ImagesCat. No.: HY-101747CAS No.: 138559-56-5ADR 851 free base is a dopamine D2 receptor antagonist,and can be used in research on antiemetics.
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(Rac)-Rotigotine hydrochloride (Standard)
0 ImagesSynonyms: N-0437 hydrochloride (Standard)(Rac)-Rotigotine (hydrochloride) (Standard) is the analytical standard of (Rac)-Rotigotine (hydrochloride). This product is intended for research and analytical applications. (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
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Thiethylperazine-d3
0 ImagesCat. No.: HY-B1794SThiethylperazine-d3 is the deuterium labeled Thiethylperazinee (HY-B1794). Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.
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Raclopride-d5 hydrochloride
0 ImagesRaclopride-d5 hydrochloride is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively.
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SKF-80723
0 ImagesCat. No.: HY-137254CAS No.: 71636-62-9SKF-80723 is a D1 receptor agonist and can be used for study of Parkinson's disease.
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Pentiapine (Standard)
0 ImagesCat. No.: HY-100143RCAS No.: 81382-51-6Synonyms: CGS 10746 (Standard)Pentiapine (Standard) is the analytical standard of Pentiapine (HY-100143). This product is intended for research and analytical applications. Pentiapine (CGS 10746) is a dopamine release inhibitor without binding to synaptic dopamine receptor sites.
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Foscarbidopa (Standard)
0 ImagesCat. No.: HY-109131RCAS No.: 1907685-81-7Synonyms: ABBV-951 (Standard); Carbidopa 4′-monophosphate (Standard)Foscarbidopa (Standard) is the analytical standard of Foscarbidopa (HY-109131). This product is intended for research and analytical applications. Foscarbidopa (ABBV-951; Carbidopa 4′-monophosphate) is a proagent of Carbidopa, acts as a dopamine receptor agonist.
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Lumateperone (Standard)
0 ImagesSynonyms: ITI-007 (Standard)Lumateperone (Standard) is the analytical standard of Lumateperone. This product is intended for research and analytical applications. Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used for the study of schizophrenia and bipolar depression.
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Aplindore fumarate
0 ImagesCat. No.: HY-129507CAS No.: 189681-71-8Synonyms: DAB-452 fumarateAplindore fumarate (DAB-452 fumarate) is a dopamine D2 receptor partial agonist. Aplindore fumarate could be used in studies of Parkinson's disease and schizophrenia.
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7-Hydroxy-PIPAT
0 ImagesCat. No.: HY-129890CAS No.: 159559-71-47-Hydroxy-PIPAT (compound 2) is a D3R agonist. 7-Hydroxy-PIPAT is a high affinity to D3 dopamine receptor with Ki value of 0.99 nM.
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L 646462
0 ImagesCat. No.: HY-118209CAS No.: 89149-85-9L-646462 is an antagonist of dopamine and 5-HT, with selectivity for the peripheral system (the central/peripheral activity ratio of L-646462 is 143). L-646462 can be used in research related to nausea, vomiting, and associated neurological disorders.
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Itopride-d6
0 ImagesCat. No.: HY-B0732ASCAS No.: 1346746-82-4Synonyms: HSR803-d6 free baseItopride-d6 (HSR803-d6 (free base)) is deuterium labeled Itopride. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD).
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Hydrastine (Standard)
0 ImagesSynonyms: (-)-β-Hydrastine (Standard); (1R,9S)-β-Hydrastine (Standard)Hydrastine (Standard) is the analytical standard of Hydrastine (HY-B0927). This product is intended for research and analytical applications. Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage.
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Fenoldopam mesylate (Standard)
0 ImagesSynonyms: Fenoldopam methanesulfonate (Standard); SKF-82526 mesylate (Standard)Fenoldopam mesylate (Standard) is the analytical standard of Fenoldopam mesylate (HY-B0735A). This product is intended for research and analytical applications. Fenoldopam (SKF-82526) mesylate is a selective dopamine D1 receptor agonist. Fenoldopam mesylate binds to rat D1B dopamine receptors (Kd = 11 nM) and human D1A receptors (Kd = 17 nM) in COS-7 cell membranes expressing the cloned receptors. Fenoldopam mesylate modulates dopamine receptor expression, induces vasorelaxation in vascular tissues, reverses glomerular hyperfiltration in rat models, increases intracellular cAMP levels, promotes DARPP-32 phosphorylation in small cell lung cancer (SCLC) cells, inhibits cytokine secretion, and downregulates T cell activation markers in activated human T cells. Fenoldopam mesylate can be used for research on hypertension, acute kidney injury, psoriasis, and small cell lung cancer.
